Bisphosphonates and Bone
نویسندگان
چکیده
Bisphosphonates are pyrophosphate analogues which were used for over a century in industry (mainly in the textile and oil industries) as antiscaling and anticorrosive agents because of their property of inhibition of calcium carbonate precipitation. After the discovery of biological effects of bisphosphonates more than 30 years ago, they have now become indispensable in medicine for the treatment of skeletal complications of malignancy, Paget’s disease, osteoporosis, multiple myeloma, hypercalcemia and fibrous dysplasia.
منابع مشابه
بررسی خواص ضدالتهابی بیس فسفونات ها (مقاله مروری)
Bisphosphonates are currently used in metabolic disorder of bone however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in-vivo. Bisphosphonates were divided in two classes regarding the structure and mechanism, including amino and non-amino bisphosphonates. The effect of bisphosphonates on cytokine related to in-vitro wa...
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Background: Osteoporosis is a common condition among the elderly population, and is associated with an increased risk of fracture. One of the most common fragility fractures involve the distal radius, and are associated with risk of subsequent fragility fracture. Early treatment with bisphosphonates has been suggested to decrease the population hip fracture burden. However, there have been no p...
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Bisphosphonates have an established role in treating tumor-induced hypercalcemia and decreasing the incidence of skeletal-related events. Recent data suggest that these agents may also prevent skeletal metastases. This review explains how cancer metastasizes to bone and how bisphosphonates may block this process, with a summary of clinical trials supporting the use of bisphosphonates to treat a...
متن کاملIn vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells
Objective(s): Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hDPSCs). Materials and Methods: The mesenchymal stem cells (MSCs), obtained ...
متن کاملBisphosphonates: expanded roles in the treatment of patients with cancer.
Bisphosphonates are important inhibitors of osteoclastic bone resorption seen in patients with bone metastases associated with malignancy. Bisphosphonates are used in the treatment of patients with bone metastases and have been shown to reduce skeletal-related events and symptoms, contributing to improved patient outcomes and quality of life. These agents first were approved in the treatment of...
متن کاملDo bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials
BACKGROUND Whether bisphosphonates affect indirect bone healing is still unclear. METHOD We carried out a comprehensive search strategy. Only randomized controlled trials were included. Two reviewers independently assessed methodological qualities and extracted outcome data. Analysis was performed with RevMan 5.2. RESULTS Eight eligible randomized controlled trials with 2,508 patients were ...
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تاریخ انتشار 2012